文章摘要
纳米羟基磷灰石/聚氨酯载药微球的制备及性能
Preparation and Properties of Nano-Hydroxyapatite/Polyurethane Drug-Loading Microspheres
  
DOI:10.16865/j.cnki.1000-7555.2017.08.003
中文关键词: 羟基磷灰石  聚氨酯  复合微球  阿莫西林  药物缓释
英文关键词: nano-hydroxyapatite  polyurethane  microsphere  amoxicillin  drug controlled release
基金项目:广东省科技计划项目(2016A010103024)
作者单位
蔡润林,邱嘉雯,洪奕玲,黄素萍,周武艺,董先明 华南农业大学 材料与能源学院/生物材料研究所, 广东 广州 510642 
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中文摘要:
      通过乳液聚合法制备了负载阿莫西林的纳米羟基磷灰石/聚氨酯(n-HA/PU)载药微球,通过正交设计实验对其制备工艺进行了优化,采用红外光谱、热重分析、扫描电镜等分析了微球的结构和性能,对其体外药物缓释过程进行探讨。研究结果表明,复合微球粒径大小与固含量、聚乙烯吡咯烷酮(PVP)含量、搅拌速度等有关,所制备的微球平均粒径为0.8~1.2mm;载药微球的优化制备工艺条件为:原料配比-NCO∶-OH=2∶1,预聚时间180min,预聚温度80℃,n-HA含量3%,固含量7%,搅拌速度600r/min,PVP用量3%,所制备微球的载药量为6.58%,包封率为86.86%。体外缓释结果表明,载药微球的释药行为符合Higuchi动力学,半衰期(t1/2)为22.29h,具有良好的药物缓释作用。
英文摘要:
      Nano-hydroxyapatite / polyurethane (n-HA / PU) microspheres with amoxicillin as model drug were prepared by suspension emulsion polymerization. Microsphere preparation process was optimized through orthogonal design experiments. The structure and properties of the microspheres were analyzed by FT-IR, TG and SEM. The results indicate that the diameter and its distributing range of microspheres have certain relationships with solid content, stirring speed and polyvinylpyrrolidone(PVP) content in the preparation process. The average diameters of microspheres are about 0.8~1.2 mm. The optimal preparation process condition of n-HA / PU drug-loading microspheres is -NCO∶-OH=2∶1 as the ratio of raw material, the prepolymerization time 180 min, the prepolymerization temperature 80 ℃, 3% of n-HA, 7% of solid content, 600 r/min of stirring speed, 3% of PVP content. The drug-loading capacity (DLC) of the microsphere is 6.58% and the encapsulation efficiency (EE) is 86.86%. The results about controlled release process in vitro show that the drug release behavior of the microspheres conforms to Higuchi dynamics, half-life t1/2 to 22.29 h, and n-HA / PU drug-loading microspheres have good drug controlled release effect.
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