文章摘要
PLLA-PEG-PLLA/Fe3O4 磁性微球的制备及性能
Preparation and Properties of PLLA-PEG-PLLA/Fe3O4 Microspheres
  
DOI:10.16865/j.cnki.1000-7555.2017.08.007
中文关键词: 聚乳酸  纳米Fe3O4  磁性微球  磁热效应  磁热疗
英文关键词: poly (lactic acid)  nano Fe3O4  magnetic microspheres  magnetocaloric effect  tumor hyperthermia
基金项目:陕西省工业攻关项目(2014K10-03)
作者单位
胡晓霞1,董 乾2,郝 红1 1.西北大学 化工学院,陕西 西安 710069; 2. 神华包头煤化工有限公司,包头 014000 
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中文摘要:
      以聚乙二醇为引发剂,L-丙交酯为单体,开环聚合得到聚乳酸-聚乙二醇三嵌段共聚物(PLLA-PEG-PLLA),采用溶剂挥发法制备了PLLA-PEG-PLLA/Fe3O4 磁性微球,并通过扫描电镜对其形态进行了表征。利用振动样品磁强计和Tg 研究了微球的磁含量和磁性能,结果发现,相同粒径不同磁含量的磁性微球,磁含量越高,升温速率越快,当磁含量为70.57%时,升温速率最快,能达到磁热疗的有效温度42℃。对于磁含量相同,粒径不同的微粒,粒径越小,升温速率越快,粒径约为10μm 时升温速率最快。
英文摘要:
      The copolymer of PLLA-PEG-PLLA was synthesized via ring-opening polymerization of L-lactide using polyethylene glycol as initiator, and the Fe3O4 nano-particles were prepared by thermal decomposition method. The PLLA-PEG-PLLA/Fe3O4 microspheres were prepared by organic solvent evaporation method, and the morphology and size of the microspheres prepared were observed by SEM. Vibrating sample magnetometer(VSM) and Tg were employed to investigate the magnetite content and magnetic properties. It is indicated that for the microspheres with the same particle size and different magnetic content, the higher the magnetite content is, the rapider the heating rate is. The heating rate of the magnetic microspheres with the magnetite content of 70.57% is the fastest, and the temperature could rise to a effective temperature of 42 ℃ for tumor hyperthermia. For the microspheres with the same magnetic content and different particle diameters, the smaller the particle diameter is, the rapider the heating rate is. The heating rate of the magnetic microspheres with the particle diameter of about 10 μm is the fastest.
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