文章摘要
生物基可降解交联聚氨酯的合成及表征
Synthesis and Characterization of Biodegradable and Crosslinked Polyurethane
  
DOI:10.16865/j.cnki.1000-7555.2017.11.005
中文关键词: 聚丙交酯  交联聚氨酯  可生物降解  生物相容性  生物工程
英文关键词: polylactide  crosslinked-polyurethane  degradation  biocompatibility  biochemical engineering
基金项目:国家自然科学基金资助项目(21374012)
作者单位
蒋晓菡, 冯学鹏, 盛 扬, 孙一新, 姜 彦, 张 嵘 常州大学 材料科学与工程学院江苏 常州 213164 
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中文摘要:
      以聚L-丙交酯(PLLA)为软段,异佛尔酮二异氰酸酯(IPDI)和甲基丙烯酸羟乙酯(HEMA)为硬段,采用两步法制备了双键封端的聚氨酯预聚物,通过UV辐射得到一种可用于生物医学材料,具有可生物降解性的交联聚氨酯(cPU)。利用核磁共振、凝胶渗透色谱、热失重及差示扫描量热分别表征了PLLA和cPU的组成、结构及热性能,此外,对cPU材料进行了力学性能和亲水性的表征及体外降解模拟实验。结果表明,增加硬段的含量,所制备的聚氨酯材料的玻璃化转变温度(Tg)和热稳定性提高,交联度、拉伸强度和降解速率增大,断裂伸长率减小;细胞实验表明,cPU材料能支持脂肪间充质干细胞(hASC)的粘附,说明cPU具有良好的生物相容性。
英文摘要:
      In this study,the soft segment of poly-L-lactide(PLLA) was synthesized by ring opening polymerization of L-lactide(L-LA) initialized by 1,4-butanediol (BDO). The reactive oligomer, which consisted of PLLA and the hard segment of isophorone diisocyanate(IPDI) and hydroxyethyl methyl acrylate(HEMA), was prepared by two-step method. PLLA and oligomers were characterized by NMR and GPC. The biodegradable crosslinked polyurethane materials(cPU) were fabricated under UV light. The cPU was characterized by thermal analysis (DSC and DMA), mechanical analysis, hydrophilic property characterization (contact angle and swelling) and analog degradation in vitro. The results show that with increasing of the partial of hard segment of cPU, increased Tg, thermal stability, crosslink density, tensile strength and degradation rate of cPU, while lowered elongation at break. Cell experiment indicates that polyurethane acrylate (PUA) materials can support the human adipose-derived stem cells(hASC) adhesion, hASC spread well on the surface of coating and demonstrate good biocompatible,and it can be used in biochemical engineering.
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