文章摘要
Polomaxer188(R)复合聚L-乳酸电纺纤维的制备及表征
Preparation and Characterization of Polomaxer188(R) Complexed Poly L-Lactic Acid Electrospun Fibers
  
DOI:10.16865/j.cnki.1000-7555.2018.02.026
中文关键词: Poloxamer188(R)  聚L-乳酸  纤维  静电纺丝  Freundlich方程
英文关键词: Poloxamer188(R)  poly L-lactic acid  fiber  electrospinning  Freundlich equation
基金项目:辽宁省自然科学基金资助项目(2014022041);中国博士后基金项目(2014M561187);国家自然科学基金资助项目(51673148)
作者单位
王 浩1,崔 银1,程博闻2,温 梦1,3,鄂义峰1,3 1.锦州医科大学 药学院,辽宁 锦州 121001
2.天津工业大学 纺织学院,天津 3003873
3.药物作用与质量评价辽宁省工程技术中心,辽宁 锦州 121001 
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中文摘要:
      考察了二氯甲烷为溶剂,Poloxamer188(R)复合聚L-乳酸均相溶液电纺纤维的形态及复合情况。将系列不同百分比的Poloxamer188(R)与聚L-乳酸共同溶解在二氯甲烷中制备成均相溶液后静电纺丝,扫描电子显微镜表征纤维的形态,X射线衍射和差示扫描量热分析表征两者的复合状况。络合显色-分光光度法测定从纤维中释放的Poloxamer188(R)量,并对时间做累积释放百分率图,采用Freundlich方程式对释放曲线进行拟合。得到了一系列直径较为均一的、无珠子的微米级纤维,随着Poloxamer188(R)复合量的增大,纤维直径先增加后减小。当Poloxamer188(R)的百分含量达到25%时,X射线图谱上开始出现其特征峰,差示扫描量热分析未见其吸热峰。Poloxamer188(R)从纤维中有明显突释,随后有约48h的缓释期,之后几乎无释放。Poloxamer188(R)在纤维中的相对百分含量越高,其每个时间点的释放量也越大。其释放曲线符合Freundlich方程式。经过Poloxamer188(R)复合,可得到直径均一的无珠子结构的聚L-乳酸电纺纤维,Poloxamer188(R)可从纤维中以逆吸附形式释放。
英文摘要:
      The morphology and complexing status of Poloxamer188(R) complexed poly L-lactic acid fibers electrospun from dichloromethane solution were investigated. Series different percentage of Poloxamer188(R) were dissolved with poly L-lactic acid in dichloromethane to form homogeneous solution to be electrospun forming fibrous membranes which were characterized by scanning electron microscope to observe the morphology, and by X-ray diffraction and differential thermal analysis to investigate the complexing status. The amount of Poloxamer188(R) released from fibrous membranes was determined by complexing-coloration spectrometry and the release curves were drew and regressed. Series of fibers of homogeneous diameter without beads structure were obtained. As the amount of complexed Poloxamer188(R) increases, fiber diameters increase first and decrease afterwards. As the percentage of Poloxamer188(R) in fibers increases to 25%, the characteristic peaks of it emerge on the X-ray diffraction patterns. There are no endothermal peaks in the differential thermal analysis curves. The burst release of Poloxamer188(R) from fibers is significant which is immediately followed by sustained release of about 48h and hardly any release thereafter. The more proportion of Poloxamer188(R) is in fibers, the bigger release amount of it is at every sampling time. The Poloxamer188(R) release curves accord with Freundlich’s equation. By being complexed with Poloxamer188(R), poly L-lactic acid electrospun fibers of homogeneous diameters without beads structure could be obtained, Poloxamer188(R) could release from the fibers by the way of inverse-adsorption.
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