文章摘要
细菌纤维素支架的复合改性及生物性能
Compound Modification and Biological Performance of Bacterial Cellulose
  
DOI:10.16865/j.cnki.1000-7555.2018.04.016
中文关键词: 细菌纤维素  多肽  复合  羟基磷灰石  生物相容性
英文关键词: bacterial cellulose  polypeptide  recombination  hydroxyapatite  biological compatibility
基金项目:国家自然科学基金资助项目(51403153);天津市科技特派员项目(16JCTPJC49200)
作者单位
王 静1,2, 徐俊青3, 吴 宁1,2, 毛丽贺1,2 1. 天津工业大学 先进纺织复合材料教育部重点实验室2. 天津工业大学 纺织学院天津 3003873. 中国天辰工程有限公司天津 300400 
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中文摘要:
      采用原花青素交联和仿生矿化技术,以生物相容性良好的细菌纤维素(BC)为原材料制备了BC/多肽(pol)和BC/多肽/羟基磷灰石(HAp)复合材料,并利用场发射扫描电镜、X射线衍射仪和红外光谱仪对制备材料进行分析表征,采用成骨细胞评估了几种支架材料的生物相容性。结果表明,交联和仿生矿化成功地将pol和HAp引入到BC的表面和内部,细胞实验表明,3种支架材料均具有一定的生物相容性,且复合改性提高了支架材料的生物活性,制备的材料具有优异的性能,是具有应用前景的组织工程支架材料。
英文摘要:
      The bacterial cellulose (BC)/polypeptide and the BC/polypeptide (pol) /hydroxyapatite (HAp) composite materials were obtained by procyanidins crosslinking and biomimetic mineralization. The prepared scaffolds were analyzed by FE-SEM, XRD and FT-IR. The osteoblast was chosen to evaluate the biocompatibility of several scaffold materials. The experimental results show that the pol and HAp could be successfully introduced to the surface and internal of BC nanofibers via crosslinking and biomimetic mineralization. Three kinds of scaffolds have certain life compatibility. The BC/pol and BC/pol/HAp composites possess better bioactivity than pure BC. The BC/pol/HAp composite has excellent performance, which has broad application prospect in the field of tissue engineering as scaffold material.
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