To increase the drug-loading capacity and stability of poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA),a terminal modification method was utilized to load cabazitaxel (CBT). Effective ways to control drugs release from micelles was conjugating drugs to polymeric materials or cross-linking polymers by chemical reaction or through similar dissolve mutually theory for combination of polymers and drugs. The target product of terminal functionalization was characterized by ¹H-NMR. The micelles encapsulation efficiency, drug loading, and drug concentration in plasma were determined by HPLC and drug plasma release assay. In conclusion, the π-π stacking effect introduced by aromatic groups increases the stability and loading capacity of polymeric micelles. The micelles have a drug loading capacity up to 71.5% for CBT. Test the plasma drug concentration, the plasma drug concentration of PEG-PLA-Bz is the best, and the drug concentration in the plasma is 2.2 μg/mL after 360 min. These results suggest that the micelles based on π-π stacking hold great potential as sustained delivery system.