文章摘要
海藻酸钠/硫酸鱼精蛋白载药微胶囊的制备及缓释性能
Preparation and In Vitro Release Property of Drug-Loaded Sodium Alginate/Protamine Sulfate Microcapsules
  
DOI:10.16865/j.cnki.1000-7555.2018.06.029
中文关键词: 海藻酸钠  层层自组装  微胶囊  缓释
英文关键词: sodium alginate  layer-by-layer self-assembly  microcapsules  controlled release
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作者单位
王 敏, 李奇霏, 张慧慧, 杨革生, 邵惠丽 纤维材料改性国家重点实验室 东华大学材料科学与工程学院上海 201620 
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中文摘要:
      直接以疏水性药物吲哚美辛微晶为模板,采用层层自组装技术,通过静电作用将聚阳电解质硫酸鱼精蛋白(PRM)和聚阴电解质海藻酸钠(ALG)交替沉积制备载药微胶囊。利用扫描电镜对其形貌进行表征,并采用紫外分光光度计考察了组装层数、释放介质的温度、离子强度、pH值等因素对其缓释性能的影响。结果表明,采用层层自组装方法可以得到(ALG/PRM)n@IDM载药微胶囊,该微胶囊对药物有显著的缓释作用,并且增加组装层数、提高释放介质的盐浓度、降低释放介质的pH值及温度均可以降低药物的释放速率。
英文摘要:
      The drug-loaded microcapsules were prepared by alternate deposition of protamine sulfate salt (PRM) and sodium alginate (ALG) onto the surface of hydrophobic indomethacin (IDM) microcrystals through layer-by-layer (LbL) self-assembly. The morphology of drug-loaded microcapsules was characterized by SEM, and the effects of assembling layer numbers, temperature, ionic strength and pH value of release medium solutions on the IDM release property were investigated by ultraviolet spectrophotometer (UV). The results show that (ALG/PRM)n@IDM microcapsules obtained by layer-by-layer (LbL) self-assembly have a prominent impact on the IDM controlled release. The drug release rate decreases as the number layers of self-assembling and the salt concentration of release medium solutions increase, and as the pH value and temperature of releasing medium drop.
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