文章摘要
聚多巴胺包覆对立构复合聚乳酸支架性能的影响
Effect of Poly(dopamine) Coating on the Performance of Stereocomplex Polylactide Scaffolds
  
DOI:10.16865/j.cnki.1000-7555.2018.08.008
中文关键词: 立构复合聚乳酸  聚多巴胺  组织工程支架
英文关键词: stereocomplex polylactide  poly(dopamine)  tissue engineering scaffold
基金项目:国家自然科学基金资助项目(51503132, 21374065)
作者单位
谢 燕, 包睿莹, 杨鸣波, 杨 伟 四川大学高分子科学与工程学院 高分子材料工程国家重点实验室四川 成都 610065 
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中文摘要:
      采用溶液浇铸和粒子沥滤的方法制备立构复合聚乳酸支架,研究了盐酸聚多巴胺溶液浸泡处理不同时间的聚多巴胺包覆立构复合聚乳酸支架的结构与性能。利用差示扫描量热、场发射电子显微镜、X射线光电子能谱分析、液滴形状分析和动态热机械分析研究了盐酸聚多巴胺溶液处理时间对立构复合聚乳酸支架的熔融行为、孔结构、表面元素组成、润湿性和储能模量的影响。结果表明,利用聚多巴胺包覆立构复合聚乳酸支架可以有效提高支架表面的亲水性,当处理时间为20 h时,聚多巴胺包覆立构复合聚乳酸支架的水接触角为0°,吸水率为421.8%;同时,在121 ℃高温下储能模量依然保持在155.3 MPa。
英文摘要:
      Stereocomplex polylactide scaffold obtained through solution casting and subsequent leaching of particles was treated with dopamine solution for different time. The melting behaviors, pore structure, surface elemental compositions, wettability and storage modulus of stereocomplex polylactide scaffolds treated with dopamine solution for different time were analyzed by differential scanning calorimeter (DSC), scanning electron microscopy (SEM), X ray photoelectron spectroscopy (XPS), drop shape analyzer (DSA) and dynamical mechanical analysis (DMA). The results indicate that poly(dopamine) coating can effectively improve the surface hydrophilicity of stereocomplex polylactide scaffold. The water contact angle of 0°, the water uptake of 421.8%, and the storage modulus of 155.3 MPa at the high temperature of 121 ℃ are achieved when stereocomplex polylactide scaffold is treated by dopamine solution with 20 h.
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