Stereocomplex polylactide scaffold obtained through solution casting and subsequent leaching of particles was treated with dopamine solution for different time. The melting behaviors, pore structure, surface elemental compositions, wettability and storage modulus of stereocomplex polylactide scaffolds treated with dopamine solution for different time were analyzed by differential scanning calorimeter (DSC), scanning electron microscopy (SEM), Xray photoelectron spectroscopy (XPS), drop shape analyzer (DSA) and dynamical mechanical analysis (DMA). The results indicate that poly(dopamine) coating can effectively improve the surface hydrophilicity of stereocomplex polylactide scaffold. The water contact angle of 0°, the water uptake of 421.8%, and the storage modulus of 155.3 MPa at the high temperature of 121 ℃ are achieved when stereocomplex polylactide scaffold is treated by dopamine solution with 20 h.