The reaction of isofronediisocyanate (IPDI) or toluene diisocyanate (TDI) with polytetrahydrofuran ether diol (PTMG) produced a linear molecular structure,followed by the addition of glycerol to obtain polyurethane prepolymerization with hyperbranched structure body, grafted with acrylate to produce hyperbranched urethane acrylate (PUA).The structure and properties of PUA were distinguished by infrared analysis and nuclear magnetic resonance spectroscopy, gel permeation chromatography and thermogravimetric analysis. The effects of the ratio of glycerin and acrylate, reaction time and temperature on the performance of PUA were discussed.The results show that the hyperbranched PUA was synthesized. It can be quickly UV cured into a 1 mm thick film within about 10 min. As the degree of crosslinking increases, the tensile strength of both PUA cured films reaches 50 MPa or more,the shear strength is close to 0.8 MPa.The PUA cured film has good water resistance and solvent resistance, the water absorption rate is below 5%, and the swelling ratio is below 300%.Soaked in 30% dilute sulfuric acid and saturated NaOH solution for 7 d,no abnormalities such as blistering, wrinkling and blushing appear.