An environment-friendly fructose-resorcinol resin adhesive synthesized by high fructose syrup(HFCS) instead of formaldehyde was prepared successfully in alkaline condition.Box-Benhnken center united experimental design was employed for experimental design and analysis of the results.Response surface methodology(RSM) was utilized for optimizing the reactive conditions.The results show that,when the mass fraction of catalyst is 6.21%,reaction temperature is 61.97 ℃ and reaction time is 5.24h,the optimal viscosity of the resultant product is 285.523 mPa·s and the bonding strength could reach 33.1MPa.