Abstract:In the present paper,the aggregation of hydrogels in millimeter size through microsopic molecular interactions was reported.Acrylamide based host hydrogels containing α-cyclodextrin(α-CD) moiety and three guest hydrogels containing phenyl,butyl and lauryl groups,respectively,were prepared.Every pairs of host/guest gels are shown to be aggregated through mutual molecular interactions of CD with the alkyl or aryl guest groups,which is supported by the dissociation of gel aggregate in the present of free α-CD molecule.Swelling experiments indicate that the good swelling state,especially for the surface part of gels,should ascribe to the inclusion of CD and guest moieties on the interfaces.