Polyethylene glycol(PEG)was reacted with Jones reagent and siloxane functionized PEG was prepared,PEG/SiO2-TiO2 hybrid sol was prepared by the hydrolysis and co-condensation of siloxane functionized PEG with TiO2 sol.Using cefazolin sodium as encapsulated drug,hybrid drug-loaded nanofiber membrane was prepared via electrospinning method.The morphology,chemical structure and drug release capability of the hybrid membrane were studied.The reaction mechanism was investigated via FT-IR spectra.SEM images showed that diameter of the hybrid nanofiber was about 115 nm,while that of the drug loaded nanofiber was about 130 nm.UV-Vis analysis showed that the drug release rate of drug-loaded fiber was high at an initial stage,and the rate decreased gradually with time prolonging,the hybrid membrane showed well performance of drug release.