In this paper, poly (ethylene terephthalate) (PET) fiber membrane was used as the substrate, and the super slippery membrane (PET-SLIPS) was fabricated by successive treatment of activation with polyamine (PDA), surface roughening with silica (SiO₂) nanoparticles produced by a sol-gel process, fluorination and lubricant filling. In the presence of PDA, SiO₂ nanoparticles are evenly distributed on the membrane surface and robustly connected with the substrate even when subjected to ultrasonic shaken or slight abrasion. The nanotextured silica coating shows good lubricant-locking ability. The contact angle of PET-SLIPS is almost unchanged after water flowing shear or abrasion, indicating the stability of the lubricant layer. The lubricant layer with fluidity can prevent immiscible liquids from contacting the membrane substrate, so that the contaminants are easy to be washed and removed and PET-SLIPS is endowed with excellent liquid repellency. Compared with the original PET membrane, PET-SLIPS shows significantly improved oil-water separation efficiency and antifouling property. In addition, the slippery membrane exhibits outstanding resistance against adhesion of biofoulings. This membrane with slippery surfaces may have application prospect in membrane separation.