Abstract:Chitosan-grafted reduced graphene oxide (CS-rGO) was successfully prepared via amide reaction. Then, CS-rGO was first used as a Self-assembled coating for surface modification of CPP porous scaffolds. CS-rGO was characterized by FITR, XPS, XRD and Raman shift; morphological observation indicates that CS-rGO is uniformly and stably distributed on the surface of CPP porous scaffold; the result of mechanical experiments shows that CS-rGO can improve the compressive strength of CPP porous scaffolds; in vitro mineralization experiment shows that CS-rGO can promote the mineralization ability of CPP porous scaffolds; Antibacterial experiment indicates that after 24 h exposure of scaffold to bacteria, about 71% of S. aureus and 66% of E. coli were inhibited in CPP/CS-rGO/0.3 scaffolds.