Polymer materials have been widely used in production and life because of their excellent properties, but it is inevitable that cracks will affect their properties. Inspired by nature, self-healing materials emerged. According to the types of repairment, the self-healing materials can be divided into extrinsic self-healing and intrinsic self-healing materials, which represent the latest development directions of materials science. The self-healing materials have received close attention and been applied in the field of leather coatings. This paper reviewed the different types of self-healing materials and the applications of self-healing materials in leather coating. The future directions of self-healing coatings in leather were discussed.