A new kind of self-healing polyurethane with multi-responses as heat, near- infrared light (NIR), and microwave was synthesized successfully via introducing Fe₃O₄ nanoparticles into Diels- Alder (DA) reaction- based thermo-reversible self-healing polyurethane (PU-DA). Results show that the introduction of Fe₃O₄ nanoparticles has no influence on the structure and thermal reversibility of PU-DA. On the contrary, the mechanical properties and selfhealing performance were improved greatly． The resultant polyurethane obtained optimal mechanical properties when the mass fraction of the introduced Fe₃O₄ nanoparticles is 0.3% . Meanwhile, the introduction of Fe₃O₄ nanoparticles not only improves the healing efficiency of thermo-reversible polyurethane markedly, but also endows polyurethane with both heat and NIR self- healing ability. Moreover, as compared to the heat repair, much quicker repair speed and higher self-healing efficiency could be reached via NIR irradiation. On the other hand, the resultant materials could be repaired repeatedly. These studies have important reference value for realizing the multi-responsive self-healing and recycling of materials.