In order to fabricate highly water- resistant and light- curing silk sericin (SS) particles, spraying drying and ultraviolet cross- linking technology were combined to prepare glycidyl methacrylate (GMA) crosslinked sericin hollow particles (GMA-g-SS) from silk sericin materials, conferring good water- resistant stability and UV curing properties. Spray drying process parameters such as SS concentration, inlet air temperature, and liquid feed rate were optimized. The effects of GMA concentration, benzophenone (BP) dosage and UV irradiation time on the grafting rate were investigated. The surface morphology, structure, and stability of as- fabricated microspheres were characterized through scanning electron microscopy, infrared spectroscopy and thermogravimetry. The results reveal that the spray- dried SS microspheres are hollow and monodispersed (diameters ranging from 5 μm to 20 μm) . The infrared spectra of GMA-g-SS microspheres show new adsorption peaks of epoxy group at 1152 cm^-1 and 764 cm^-1, suggesting the GMA and SS were successfully cross-linked. After crosslinking, the SS microspheres are in an adherent state, with high UV curing performance and greatly improved water stability (mass-loss ratio is only 17.1%). The prepared GMA-g-SS microspheres have tunable water stability and UV curing performance, making them a potential biomaterial for UV-curing 3D printing.