In order to explore the influence on sintering temperature to the friction and wear performance of graphene- filled polyetheretherketone/polytetrafluoroethylene(PEEK/PTFE) composite during preparation, the models of 10%PEEK/PTFE and 1%Graphene/10%PEEK/PTFE were constructed based on molecular dynamics simulation method. And then the parameters of the corresponding mechanical and tribological properties of composite were obtained. Under different sintering temperatures, the samples of 10% PEEK/PTFE and 1% Graphene/10%PEEK/PTFE were prepared, then the friction wear test and wear morphology analysis were carried out. The results show that the friction and wear characteristics of the PEEK/PTFE composite material can be effectively improved by graphene, and different sintering temperatures have varying degrees of influence on the intermolecular forces, material mechanical properties, and friction characteristics of the composite materials. When the sintering temperature is 360 ℃ , the intermolecular forces, material mechanical properties, and friction characteristics of the composite materials all reach their peaks.