纤维素/海藻酸钠/明胶复合水凝胶的制备与性能
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国家自然科学基金资助项目(22109054)


Preparation and Properties of Cellulose/Sodium Alginate/Gelatin Composite Hydrogel
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    摘要:

    纤维素作为一种来源丰富的天然高分子材料,具有优异的生物相容性和可降解性,但其难溶特性限制了其应用。文中采用离子液体1-烯丙基-3-甲基咪唑氯化物(AmimCl)溶解纤维素(Cel),海藻酸钠(SA) 与明胶(Gel) 混合水溶液作为凝固浴进行纤维素再生,进一步通过浸泡氯化钙(CaCl2)溶液交联海藻酸钠,制备了一种透明、高强度的复合水凝胶。分别探究了纤维素浓度(3%,4%,5%,6%,7%和8%)及不同的海藻酸钠/明胶质量比(0:10,2:8,4:6,6:4,8:2和10:0)对水凝胶性能的影响。利用傅里叶变换红外光谱、扫描电子显微镜、X射线衍射仪、紫外可见分光光度计和万能材料试验机对水凝胶进行了表征。结果表明,水凝胶中各组分之间的氢键作用及海藻酸钠与Ca2+之间的离子相互作用赋予水凝胶优异的力学性能,相比于纯水作为凝固浴制备的再生纤维素水凝胶,强度提高了26.36%。随着纤维素浓度的增加,水凝胶的结晶度和网络结构的致密性增加,水凝胶的力学性能显著提升。此外,海藻酸钠/明胶的比例也对水凝胶的力学性能有显著影响,当海藻酸钠与明胶质量比为6:4 时,水凝胶力学性能最好,最高达到2.349 MPa。生物降解性分析表明,水凝胶具有良好的生物降解性,在食品包装和生物医药领域具有潜在应用价值。

    Abstract:

    As a natural polymer material with abundant sources, cellulose has good biocompatibility and degradability, but its application was limited due to its difficulty in dissolution. In this paper, the ionic liquid 1-allyl-3-methylimidazole chloride (AmimCl) was used to dissolve cellulose (Cel). The mixed aqueous solution of sodium alginate (SA) and gelatin (Gel) was used as coagulation bath to regenerate cellulose. Then, a transparent, high- strength composite hydrogel was prepared by soaking in calcium chloride solution for crosslinking sodium alginate. The effects of cellulose concentration (3%, 4%, 5%, 6%, 7% and 8%) and different sodium alginate/gelatin mass ratios (0:10, 2:8, 4:6, 6:4, 8:2 and 10:0) on the performance of hydrogels were investigated respectively. The physical properties of the hydrogels were characterized by FT- IR, SEM, XRD, UV- Vis and universal material testing machine. The results show that the hydrogen bonding between the components in hydrogel and the ion interaction between sodium alginate and Ca2+ endow the hydrogels with excellent mechanical properties. Compared with the regenerated cellulose hydrogel prepared with pure water as coagulation bath, the strength is increased by 26.36%. With the increase of cellulose concentration, the crystallinity of the hydrogels and density of the network structure increase, and the mechanical properties of the hydrogels are significantly improved. In addition, the ratio of sodium alginate to gelatin also has a significant impact on the performance of the hydrogels. When the mass ratio of sodium alginate to gelatin is 6:4, the mechanical performance of the hydrogel is best, which can reach 2.349 MPa. The degradability test shows that the hydrogel has good biodegradability, which has a wide range of potential applications.

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王斐昊,许波,王平,王强.纤维素/海藻酸钠/明胶复合水凝胶的制备与性能[J].高分子材料科学与工程,2024,40(3):133-142. Feihao Wang, Bo Xu, Ping Wang, Qiang Wang. Preparation and Properties of Cellulose/Sodium Alginate/Gelatin Composite Hydrogel[J]. Polymer Materials Science & Engineering,2024,40(3):133-142.

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