Natural polymer hydrogels have attracted much attention due to their good biocompatibility, biodegradability and easy availability. Among them, self-healing natural polymer hydrogels have unique advantages such as self-healing ability, maintaining the integrity of structure and properties, and long-term functional stability. Recently, they have become as a research hotspot in the fields of biomedicine and tissue engineering. This review mainly introduced the latest research progress in the field of self-healing natural polymer hydrogel, i.e. collagen, cellulose, chitosan and hyaluronic acid self-healing hydrogels, as well as the self-healing hydrogels with temperature, pH and light stimulus-responsiveness, summarized the healing mechanism of self-healing hydrogel, and looked forward to the challenges and future development directions of self-healing hydrogel.