The difluoro-substituted long-chain ether amine soft segment and semi-aromatic amide hard segment were prepared via interfacial electrophilic substitution reaction. A series of novel polyamide elastomers with different hard segment structures were obtained by solution polycondensation at atmospheric pressure with above monomers and hydroquinone. The chemical structures of monomers and polymers were characterized by infrared spectroscopy (FT-IR) and nuclear magnetic resonance (1H-NMR). The results of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) show that the prepared elastomers have excellent thermal properties (melting point between 248～300 ℃ and thermal decomposition temperature higher than 380℃). The relationship between aggregation and molecular structure was studied by wide angle X-ray diffraction (WAXD), suggesting the similar crystallization behavior. Vicat softening temperature analysis (VST) show that these polymers have higher service temperature. The tensile strength and elongation at break were characterized by tensile test. The results show that this kind of polymer has excellent thermal and mechanical properties, and its maximum deformation can reach 350%. It is expected to be used as special elastomer material in high temperature and corrosive environment.