Using styrene (St) and methyl methacrylate (MMA) as hard monomer, butyl acrylate (BA) as soft monomer, vinyltrimethoxysilane (A-171) and diacetone acrylamide (DAAM) as crosslinking monomer in the core and shell layers, respectively, the self-crosslinking modified core-shell acrylate emulsions were synthesized at room temperature. The effects of initiator type and dosage, crosslinking monomer addition on emulsion polymerization were investigated. Successful cross-linking of the cross-linking monomers was proved by ATR-FTIR, and the emulsions were characterized by DLS and TEM, which proved the successful synthesis of homogeneous core-shell emulsion. The results prove that the emulsions were polymerized by semi-continuous seed emulsion polymerization with the initiator m(KPS):m(NaHSO3)=2:1, the initiator dosage of 0.4%, and the mass fractions of self-cross-linking monomer vinyltrimethoxysilane (A-171) in the core layer and self-cross-linking monomer bis (acetone acrylamide) (DAAM+ADH) in the shell layer of 3% and 2%, respectively, and the emulsions have good stability, water resistance and film-forming property, with the conversion rate above 90%, water absorption rate above 90%, the water absorption rate is 6.87%, and the calcium ion stability is qualified. Compared with the non-crosslinked monomer emulsion without core-shell, the thermal decomposition temperature of TG is increased by 41 ℃, which alleviates the problems of poor water resistance, poor solvent resistance, and "hot sticking and cold brittleness" of water-based ink coating.