Bacterial infections can cause wound inflammation, make wound healing difficult, and there is an urgent need to develop intelligent hydrogel dressings that are highly effective in their antibacterial, anti-inflammatory properties, and can promote re-epithelialization and angiogenesis. The pH sensitive antibacterial hydrogel IA/ AM /TAAC@PHMG was prepared by one pot method using itaconic acid (IA), acrylamide (AM) and allyl trimethylammonium chloride (TAAC) as raw materials for covalent cross-linking, loaded with the antibacterial drug polyhexamethylene guanidine hydrochloride (PHMG). The mechanical properties, swelling properties, drug release properties, antimicrobial properties, biocompatibility, and pro-infectious wound healing properties were tested. The results show that TAAC increases the flexibility of hydrogels and the breaking elongation of hydrogels is increased by 88%; the hydrogels are pH-responsive, can respond positively to wound, pH, control and prolong the release of PHMG, The release rate of PHMG under alkaline conditions (pH 8.2) (60.65%) is better than 14.97% under acidic conditions (pH 3.2); the antibacterial rate of IA/AM/TAAC@PHMG against E. coli and S. aureus is over 99.98%; the cell relative survival rate in the hydrogel group (320 μg/mL) is above 75.08%, the cell hemolysis rate is below 4%, the antibacterial hydrogel has a good biocompatibility; histological analysis prove that the IA/ AM /TAAC@PHMG loaded hydrogel can create an environment conducive to granulation growth and excellent antibacterial properties, to reduce the inflammatory factors, promote both collagen and skin regeneration, accelerate wound healing.