Photovoltaic panels urgently need self-cleaning or easy-to-clean functions in applications, in this study, a super slippery self-cleaning coating with anti-reflection effect on photovoltaic panels was developed, the coating was prepared with silicone resin, methyl silicone oil, epoxy resin and silane coupling agent. This super slippery hydrophobic coating was configured with a uniform solution, it was prepared by convenient lifting and brushing process. The coating has a sliding property of less than 10° for water-based liquids such as pure water and methyl blue, and the static water contact angle can reach 109°, showing hydrophobic characteristics. The coating has a sliding property of less than 10° for water-based liquids such as pure water and methyl blue, and the static water contact angle can reach 109°, showing hydrophobic characteristics. The coating also has excellent stability. After polishing 100 cycles with 400 mesh sandpaper, the coating performance basically remains unchanged, and the adhesion strength to the substrate is high. After 30 d of placement, the coating is still well bonded. Compared with the bare glass surface, the optical anti-reflection rate is about 2%~3%, when applied to the solar cell surface, the initial efficiency has a 0.18% improvement. In addition, the super slippery coating also has remarkable hydrophobic, anti-fouling and self-cleaning properties, showing potential application value in photovoltaic field.