Conductive hydrogel strain sensors achieve real-time monitoring functions by converting mechanical deformation into electrical resistance signals, and their performance optimization relies on the synergistic enhancement of mechanical strength, adhesion, sensitivity and environmental adaptability. Aiming at the bottlenecks of uneven dispersion, weak interfacial bonding, and single function of conductive fillers, this study is based on the “ dual network interpenetration-multifunctional group coupling” strategy. Methacrylated silk fibroin (SFMA) was used as gel backbone, while sodium lignosulfonate-doped polyaniline (LS@PANI) was employed as conductive matrix, resulting in the formation of a homogeneously dispersed conductive network. The first gel network was formed through dynamic cross-linking of polyvinyl alcohol ( PVA) and borax, while the second interpenetrating network was constructed via UV-induced cross-linking of SFMA double bonds. The resulting SFMA / PVA-Borax / LS@PANI hydrogel sensor integrates mechanical performance, self-healing properties, selfadhesion, and high sensitivity. Experimental results demonstrate that with 8% SFMA mass fraction, the hydrogel achieves a tensile strain of 1206% and tensile strength of 13.7 kPa, while maintaining complex deformations such as knotting and twisting. Self-healing functionality is enabled by dynamic borate ester bonds, and robust adhesion to diverse substrates is attributed to active groups ( amino, carboxyl, and catechol groups), allowing conformal attachment to human skin and residue-free detachment. Furthermore, with a stable resistance response across 0 ~ 500% strain and the capability to monitor both joint movements and facial micro-expressions, the sensor highlights its application potential in the field of flexible wearable sensing.